Selphyl® Platelet-Rich Fibrin Matrix (PRFM). Platelet Rich Plasma (PRP), is the concentration of your blood’s platelets, which when applied or injected to the skin, promotes a rapid healing response. PRFM takes the healing and rejuvenating powers of PRP and adds a “scaffolding” to preserve and protect the platelets. It also purifies the PRP, so what you are getting is 100% pure platelets, without any red or white blood cells creeping in to the mix. PRFM uses the power of your blood’s platelets to rejuvenate skin and reinvigorate cellular turnover. Platelets have the unique ability to rev up collagen production. PRFM injections are to improve skin texture and moisture. PRFM may be injected under the eyes, cheeks, fine lines around the mouth, and lips.